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Transcatheter mitral valve replacement: tissue in-growth after 4 weeks
Georg Lutter1,2, Lennart Bax1,3, Yazhou Liu1,2
1Department of Experimental Cardiac Surgery and Heart Valve Replacement, Christian-Albrechts-University of Kiel, School of Medicine, UKSH, Kiel, Germany.
Interactive Cardiovascular and Thoracic Surgery
|December 6, 2020
Summary
This study shows transcatheter mitral valve replacement stents integrate well into the mitral annulus with minimal tissue reaction. Histological analysis revealed progressive healing and neointimalization in animal models.
Area of Science:
- Cardiovascular research
- Biomaterials science
- Surgical innovation
Background:
- Transcatheter mitral valve replacement (TMVR) is an emerging technique.
- Understanding tissue response to implanted devices is crucial for clinical success.
Purpose of the Study:
- To investigate the tissue reaction to transcatheter-delivered mitral valve replacement stents in a porcine model.
- To evaluate the integration and healing of these devices in the mitral annulus.
Main Methods:
- Trileaflet porcine pericardial valves were mounted on nitinol stents and delivered transapically off-pump in 10 pigs.
- Follow-up included gross pathological and histological examination with special staining and immunohistochemistry.
Main Results:
- Successful stent positioning in 9/10 animals, with good integration into the left atrium and mitral annulus.
- Histological examination showed minimal tissue reaction to nitinol struts and well-preserved surrounding structures in most cases.
- Evidence of progressive healing and neointimalization was observed.
Conclusions:
- This study provides the first evidence of good in-growth for transcatheter mitral valve replacement stents.
- The findings suggest a favorable tissue response and healing process for these anatomically shaped devices.
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