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Next-Generation Antibiotics, Bacteriophage Endolysins, and Nanomaterials for Combating Pathogens
I G Shemyakin1, V V Firstova2, N K Fursova1
1State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, 142279, Russia.
Biochemistry. Biokhimiia
|December 7, 2020
Summary
New antibiotics and microbiome editing offer personalized treatments against infectious diseases. Strategies include CRISPR-Cas systems, bacteriophage endolysins, and nanomodified implants to combat resistant bacteria and infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Biotechnology
Background:
- Antibiotic resistance is a growing threat to global health.
- Existing treatments face challenges like bacterial persistence and postoperative infections.
- Novel strategies are needed to combat diverse microbial pathogens.
Purpose of the Study:
- To review current and emerging strategies for combating infectious disease agents.
- To explore the potential of microbiome editing, CRISPR-Cas systems, and bacteriophage endolysins.
- To discuss nanomodifications for antibacterial implants and their properties.
Main Methods:
- Review of literature on antimicrobial strategies.
- Analysis of programmable RNA-antibiotics and microbiome editing.
- Examination of CRISPR-Cas systems for bacterial control.
- Evaluation of bacteriophage endolysins against resistant bacteria.
- Assessment of nanomodifications for implant-associated infections.
Main Results:
- Programmable RNA-antibiotics enable personalized microbiome editing.
- CRISPR-Cas systems offer precise genome editing for bacterial infections.
- Bacteriophage endolysins show efficacy against resistant bacteria and biofilms.
- Nanomodifications (silver, boron nitride, nanofibers) enhance implant antibacterial properties.
Conclusions:
- Next-generation personalized drugs based on microbiome editing are promising.
- CRISPR-Cas and bacteriophage endolysins represent powerful tools against resistant bacteria.
- Nanomodified implants offer a viable approach to prevent postoperative infections.
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