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Childhood bullous lichen planus.
D J Kwee1, R G Dufresne, D L Ellis
1Division of Dermatology, Vanderbilt University, Nashville, Tennessee.
Pediatric Dermatology
|December 1, 1987
Summary
A child with bullous lichen planus refractory to antibiotics showed IgA and IgG deposits in the skin. Dapsone treatment successfully resolved the bullous lesions, confirming the diagnosis.
Area of Science:
- Dermatology
- Immunopathology
Background:
- Lichen planus is an inflammatory condition that can affect the skin, hair, nails, and mucous membranes.
- Bullous lichen planus is a rare variant characterized by the formation of blisters.
Observation:
- A pediatric patient presented with bullous lesions unresponsive to antibiotic therapy.
- Histopathological examination of a bulla revealed characteristic changes of bullous lichen planus.
Findings:
- Indirect immunofluorescence demonstrated IgA and IgG deposition in the stratum granulosum and stratum corneum of perilesional skin.
- These findings confirmed the diagnosis of bullous lichen planus.
Implications:
- The study highlights the diagnostic utility of immunofluorescence in bullous lichen planus.
- Dapsone emerged as an effective treatment, suggesting its role in managing this condition.