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[Macrolides and immunity].

M T Labro1

  • 1INSERM U294, Laboratoire d'hématologie et d'immunologie, CHU Xavier-Bichat, Paris.

La Revue De Medecine Interne
|November 1, 1987
PubMed
Summary

Macrolide antibiotics, known for over 30 years, are being explored for immunostimulating properties to combat bacterial resistance. Research shows these compounds can concentrate in phagocytes and may enhance host defense, warranting further investigation into structure-activity relationships.

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Area of Science:

  • Pharmacology
  • Immunology
  • Microbiology

Context:

  • Growing bacterial resistance necessitates novel therapeutic strategies.
  • Macrolide antibiotics have a long history but their immunomodulatory effects are under-explored.
  • Phagocytes are key components of the host defense system.

Purpose:

  • To review existing literature on the interaction between macrolide antibiotics and the host defense system.
  • To highlight the immunostimulating potential of macrolides in combating bacterial infections.
  • To identify knowledge gaps regarding structure-immunomodulating activity relationships.

Summary:

  • Macrolides exhibit significant penetration and concentration within phagocytes.
  • While some depressive effects on phagocyte function are noted, several macrolides demonstrate in vitro and ex vivo immunostimulating effects.
  • This review consolidates current data on macrolide-host defense interactions.

Impact:

  • Provides a comprehensive overview of macrolide immunostimulatory properties.
  • Suggests macrolides as potential candidates for novel antibiotic therapies targeting bacterial resistance.
  • Underscores the need for further research into structure-activity relationships for optimized immunomodulatory drug design.

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