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Related Experiment Video

Updated: Nov 27, 2025

Observation and Analysis of Blinking Surface-enhanced Raman Scattering
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Observation and Analysis of Blinking Surface-enhanced Raman Scattering

Published on: January 11, 2018

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Repetitive optical coherence elastography measurements with blinking nanobombs.

Paul Boerner1,2, Dmitry Nevozhay3,2, Maryam Hatamimoslehabadi1

  • 1Department of Biomedical Engineering, University of Houston, Houston, Texas 77204, USA.

Biomedical Optics Express
|December 7, 2020
PubMed
Summary

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Repetitive laser excitation of C6 nanobombs generates longitudinal shear waves (LSW) for material elasticity assessment. This enables continuous tissue mechanical property quantification from a single nanoparticle injection.

Area of Science:

  • Biomedical Engineering
  • Acoustic Imaging
  • Nanotechnology

Background:

  • Dye-loaded perfluorocarbon nanoparticles (nanobombs) generate localized longitudinal shear waves (LSW).
  • LSW enable tissue mechanical property quantification without transversal scanning.
  • Repetitive nanobomb excitation allows for multiple LSW generation from a single spot.

Purpose of the Study:

  • To investigate the feasibility of using repetitive laser excitations of dodecafluoropentane (C5) and tetradecafluorohexane (C6) nanobombs for elastography.
  • To assess the potential of C6 nanobombs for continuous quantification of tissue mechanical properties.

Main Methods:

  • Utilized nanosecond-pulsed laser to excite C5 and C6 nanobombs in a phantom.
  • Employed a 1.5 MHz Fourier-domain mode-locked laser with a phase correction algorithm for elastography.

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  • Monitored nanobomb activations using photoacoustic signal detection.

    • Main Results:

    • Demonstrated repetitive generation of LSW from a single spot using C6 nanobombs.
    • Successfully quantified material elasticity using the generated LSW.
    • Confirmed the feasibility of monitoring nanobomb activations via photoacoustic signals.

    Conclusions:

    • C6 nanobombs are suitable for repetitive LSW generation for material elasticity assessment.
    • This technology offers a novel approach for continuous quantification of tissue mechanical properties.
    • Single nanoparticle delivery can facilitate ongoing mechanical property monitoring.