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Related Experiment Video

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Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
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Scruples over Speckles.

Benjamin Persons1, Eugene Y Kissin1

  • 1Division of Rheumatology, Boston University Medical Center, Boston, MA, USA.

Journal of Medical Ultrasound
|December 7, 2020
PubMed
Summary
This summary is machine-generated.

The ultrasound "snowstorm" sign, typically indicating gout, can also be caused by other conditions. This finding expands the differential diagnosis for this specific ultrasound appearance in rheumatology.

Keywords:
Calcium pyrophosphategoutrice bodysnowstorm

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Area of Science:

  • Rheumatology
  • Medical Imaging
  • Ultrasound Diagnostics

Background:

  • The "snowstorm" sign on ultrasound, characterized by motile hyperechoic specks in synovial fluid, is highly specific for gout.
  • This sign is crucial for diagnosing crystal-induced arthropathies.

Purpose of the Study:

  • To identify and describe alternative etiologies that mimic the ultrasound "snowstorm" sign.
  • To broaden the differential diagnosis for this specific sonographic finding.

Main Methods:

  • Retrospective analysis of ultrasound images from rheumatology patients.
  • Correlation of sonographic findings with clinical diagnoses and synovial fluid analysis.

Main Results:

  • Identified calcium pyrophosphate deposition disease as a cause of the "snowstorm" sign.
  • Demonstrated that fibrin collections/rice bodies can also present as a "snowstorm" appearance.
  • Showcased gas bubbles in viscous synovial fluid as another mimic of the "snowstorm" sign.

Conclusions:

  • The "snowstorm" sign is not exclusively indicative of gout.
  • Clinicians should consider calcium pyrophosphate deposition disease, fibrin, and gas bubbles in the differential diagnosis of the ultrasound "snowstorm" sign.