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Published on: June 11, 2020
Ameliorating Effects of Ginger on Isoproterenol-Induced Acute Myocardial Infarction in Rats and its Impact on Cardiac
1Department of Pharmacy Practice, College of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Insights
Ginger extract offers a protective role against heart damage caused by Isoproterenol (ISO), primarily through its antioxidant and anti-inflammatory properties. This natural compound may help mitigate ISO-induced cardiotoxicity by influencing nitric oxide (NO) levels.
Area of Science:
- Cardiovascular Research
- Pharmacology
- Natural Product Chemistry
Background:
- Myocardial infarction (MI) is a leading cause of global mortality and morbidity.
- Isoproterenol (ISO)-induced MI is a validated model for studying cardioprotective agents.
- Nitric Oxide (NO) plays a complex role, potentially contributing to oxidative stress in MI.
Purpose of the Study:
- To evaluate the antioxidant and cardioprotective effects of ginger extract in a rat model of ISO-induced acute myocardial infarction.
- To specifically investigate the impact of ginger on nitric oxide (NO) levels during ISO-induced cardiotoxicity.
Main Methods:
- Forty male albino rats were divided into four groups: control, ginger extract only, ISO-induced MI, and ginger extract followed by ISO-induced MI.
- Ginger extract was administered orally.
- Myocardial infarction was induced via subcutaneous ISO administration.
Main Results:
- Ginger extract demonstrated a significant protective role against ISO-induced myocardial infarction.
- The cardioprotective effects are attributed to ginger's potent antioxidant and anti-inflammatory properties.
- Ginger administration influenced nitric oxide (NO) levels, suggesting a role in modulating oxidative stress.
Conclusions:
- Ginger extract effectively protects against acute myocardial infarction induced by ISO in rats.
- The cardioprotective mechanism involves antioxidant and anti-inflammatory actions, potentially through modulation of nitric oxide pathways.
- Further research, including immunohistochemical and biochemical studies, is warranted to elucidate the molecular mechanisms.
Background:
Myocardial infarction is a major heart disease and is considered a significant reason for mortality and morbidity around the world. The model of Isoproterenol (ISO)-induced myocardial infarction provides a supported method for investigating the impacts of numerous possible cardioprotective bioactive substances. Nitric Oxide (NO) could react with reactive oxygen intermediates and free radicals to create harmful species. For several years, researchers have investigated the use of herbs and natural products as antioxidants to protect the body's organs against toxins and drug metabolites. However, studies on the antioxidant effects of ginger against cardiotoxicity induced by drugs and toxic agents remain insufficient, especially its effects on NO.
Aims And Objectives:
This study aimed to investigate the possible antioxidant and protective role of ginger in ISO-induced acute myocardial infarction in experimental rats. Special emphasis was given to the impact of ginger on NO levels.
Materials And Methods:
Forty adult male albino rats were used in this study. The animals were randomly divided into four equal groups. Group I served as control and received a normal mouse diet. Group II received ginger extract orally, Group III received normal diet for eight weeks, followed by ISO administration subcutaneously to induce myocardial infarction, Group IV received ginger extracts, followed by ISO.
Results And Conclusions:
The results of this study illustrated ginger's protective role against ISO-induced acute myocardial infarction. This role is mainly due to ginger's antioxidant and anti-inflammatory properties. We assume that sufficient intake of ginger by individuals who are regularly exposed to ISO would be beneficial in overcoming the cardiotoxicity of ISO. The effects of ginger may take place through inhibition of NOS enzymes, which needs further immunohistochemical and biochemical studies to reveal the underlying different mechanisms of the effects of ginger at the molecular and structural levels.
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