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Overview of Plasma and Platelet Transfusions in Critically Ill Children

Stacie Kahn1, Madhuradhar Chegondi2, Marianne E Nellis3

  • 1Division of Pediatric Critical Care Medicine, NewYork-Presbyterian, Morgan Stanley Children's Hospital, New York, NY, United States.

Frontiers in Pediatrics
|December 7, 2020
PubMed

Insights

Plasma and platelet transfusions are common in critically ill children, but clear indications for use are lacking. This review examines current evidence, risks, and benefits for pediatric intensive care hemostasis.

Area of Science:

  • Pediatric Critical Care Medicine
  • Transfusion Medicine
  • Pediatric Hematology

Background:

  • Critically ill children often receive plasma and platelet transfusions.
  • Indications for these transfusions in pediatric intensive care are not well-defined.
  • Practices vary significantly among healthcare providers and institutions.

Purpose of the Study:

  • To review current evidence on plasma and platelet transfusions for hemostasis in pediatric intensive care.
  • To describe product composition, epidemiology, and indications for use.
  • To discuss potential risks, benefits, knowledge gaps, and future research.

Main Methods:

  • Literature review of existing evidence.
  • Analysis of product composition and epidemiological data.
  • Discussion of clinical indications, risks, and benefits.

Main Results:

  • Current evidence on transfusion indications in pediatric intensive care is limited.
  • Plasma and platelet transfusions carry potential risks and benefits.
  • Significant knowledge gaps exist regarding optimal transfusion strategies.

Conclusions:

  • Further research is needed to establish clear transfusion guidelines for critically ill children.
  • Optimizing transfusion practices can improve hemostasis and patient outcomes.
  • Evidence-based recommendations are crucial for consistent care.

Keywords:
critical ill childrenhemorrhagehemostasisplasmaplatelet transfusion

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