Related Experiment Video

Updated: Nov 27, 2025

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
11:13

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

38.0K

Regulation of the JAK2-STAT5 Pathway by Signaling Molecules in the Mammary Gland

Min Tian1, Yingao Qi1, Xiaoli Zhang1

  • 1Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.

Frontiers in Cell and Developmental Biology
|December 7, 2020
PubMed

Insights

The Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) pathway is crucial for mammary gland cells. Its dysregulation and crosstalk with other pathways contribute to breast cancer development.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • The Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) pathway regulates mammary gland epithelial cell functions like proliferation, differentiation, and survival.
  • Aberrant JAK2-STAT5 signaling is linked to mammary gland developmental issues and diseases, notably breast cancer.
  • This pathway's normal function depends on intricate crosstalk with various other signaling cascades.

Purpose of the Study:

  • To review recent advancements in understanding the JAK2-STAT5 signaling pathway.
  • To explore the critical components of the JAK2-STAT5 pathway.
  • To elucidate the crosstalk between JAK2-STAT5 signaling and other key pathways.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of signaling pathway interactions.
  • Focus on molecular mechanisms and biological outcomes.

Main Results:

  • Recent progress in identifying critical components of the JAK2-STAT5 pathway has been highlighted.
  • The review details the crosstalk of JAK2-STAT5 with G-protein coupled receptor (GPCR) signaling, PI3K-Akt signaling, growth factors, inflammatory cytokines, hormone receptors, and cell adhesion molecules.
  • Understanding these interactions is key to normal biological performance and disease prevention.

Conclusions:

  • The JAK2-STAT5 pathway is a central regulator of mammary gland function.
  • Crosstalk with diverse signaling pathways is essential for JAK2-STAT5 pathway regulation.
  • Further research into these interactions may reveal new therapeutic targets for breast cancer and other mammary gland diseases.
Keywords:
JAK2Stat5mammary gland developmentmilk productionsignaling molecules

More Related Videos

Differentiation of Mouse Breast Epithelial HC11 and EpH4 Cells09:32

Differentiation of Mouse Breast Epithelial HC11 and EpH4 Cells

Published on: February 27, 2020

9.3K
Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands11:31

Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands

Published on: May 30, 2017

10.3K

Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
10.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.2K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
4.8K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.9K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
9.7K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
15.6K