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MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways

Dwitiya Sawant1, Brenda Lilly1,2

  • 1Center for Cardiovascular Research and The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA.

Vascular Biology (Bristol, England)
|December 7, 2020
PubMed

Insights

MicroRNAs (miRNAs), like miR-145, regulate gene expression and act as tumor suppressors. This review compares miR-145

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology
  • Cardiovascular Biology

Background:

  • MicroRNAs (miRNAs) are small regulatory RNAs controlling gene expression post-transcriptionally.
  • miR-145 is a significant miRNA involved in diverse biological processes.
  • miR-145 functions as a tumor suppressor and plays critical roles in the cardiovascular system.

Purpose of the Study:

  • To review the mechanisms of miR-145 in tumorigenesis and cancer progression.
  • To compare and contrast miR-145's roles in cancer with its functions in cardiovascular development and disease.
  • To discuss miR-145 targets in cancer and their potential link to cardiovascular health.

Main Methods:

  • Literature review of existing studies on miR-145.
  • Comparative analysis of miR-145 functions across different biological systems.
  • Identification and discussion of key miR-145 target genes.

Main Results:

  • miR-145 regulates key signaling pathways in tumor growth and progression.
  • miR-145 is crucial for cardiovascular development and implicated in cardiovascular diseases.
  • Shared and distinct molecular targets of miR-145 in cancer and cardiovascular contexts were identified.

Conclusions:

  • miR-145 exhibits dual roles in cancer suppression and cardiovascular regulation.
  • Understanding miR-145's multifaceted functions can reveal therapeutic strategies for both cancer and cardiovascular diseases.
  • Further research into the interconnectedness of miR-145 pathways may offer novel treatment avenues.
Keywords:
cancercardiovascularmiR-145smooth muscle

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