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Metabolic Syndrome and Cognitive Function in Midlife.

Janelle T Foret1, Stephanie Oleson2, Brennan Hickson3

  • 1Department of Psychology, The University of Texas at Austin, Austin, TX, USA.

Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists
|December 7, 2020
PubMed
Summary

Metabolic syndrome (MetS) components in middle-aged adults are linked to poorer executive function and memory. Early detection and intervention for MetS may help preserve cognitive health.

Keywords:
AgingBrainCognitive impairmentExecutive functionMetabolic syndromeNeuropsychological assessment

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Area of Science:

  • Neuroscience
  • Cardiovascular Health
  • Cognitive Aging

Background:

  • Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors.
  • MetS is associated with cognitive decline, particularly in executive functions.
  • Frontal lobe regions critical for executive function are vulnerable to cardiovascular disease.

Purpose of the Study:

  • To investigate the relationship between MetS and cognitive function in middle-aged adults.
  • To determine if the number of MetS components correlates with cognitive performance.
  • To explore the association of MetS diagnosis with executive function and memory.

Main Methods:

  • 197 adults aged 40-60 participated in the study.
  • Metabolic syndrome was assessed using established diagnostic criteria.
  • Cognitive domains including global cognition, executive function, and memory were evaluated using standardized tests.

Main Results:

  • A higher number of MetS components was significantly associated with poorer executive function.
  • MetS components also showed a significant relationship with diminished memory performance.
  • While MetS diagnosis was not linked to executive function, it was significantly associated with poorer memory scores.

Conclusions:

  • Findings support the link between midlife MetS components and executive dysfunction.
  • MetS and its components are associated with impaired memory function in middle age.
  • Cognitive vulnerability related to MetS can be identified in midlife, suggesting potential for intervention.