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Dysthyroidism in dermato/polymyositis patients: A case-control study
Abdulla Watad1,2,3, Nicola L Bragazzi4, Giovanni Damiani5,6
1Department of Medicine 'B', The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
European Journal of Clinical Investigation
|December 7, 2020
Summary
Dermatomyositis and polymyositis patients show a higher prevalence of thyroid dysfunction, specifically hypothyroidism and hyperthyroidism. Regular thyroid screening is recommended for individuals with these autoimmune conditions.
Area of Science:
- Rheumatology
- Endocrinology
- Autoimmune Diseases
Background:
- Dermatomyositis (DM) and polymyositis (PM) are rare autoimmune disorders.
- An association with dysthyroidism (thyroid dysfunction) has been occasionally suggested but not definitively proven.
Purpose of the Study:
- To investigate the prevalence of dysthyroidism in patients diagnosed with DM or PM.
- To analyze the association between DM/PM and thyroid dysfunction.
Main Methods:
- A nationwide case-control study utilized data from 2085 DM/PM patients and 10,193 matched controls (2000-2018).
- Univariate, multivariate logistic regression, and survival analyses were performed to assess the link between dysthyroidism and PM/DM.
Main Results:
- Hypothyroidism was significantly more prevalent in DM/PM patients (11.2%) compared to controls (8.4%).
- Hyperthyroidism was also significantly higher in cases (1.9%) versus controls (1.2%).
- Multivariate analysis confirmed significant associations of both DM and PM with hypothyroidism, and DM with hyperthyroidism.
Conclusions:
- The study establishes a significant link between DM/PM and thyroid dysfunction.
- Physicians should consider regular thyroid function screening for patients with DM or PM.
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