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Small Molecule Approaches for Targeting the Polycomb Repressive Complex 2 (PRC2) in Cancer

M Cynthia Martin1, Guihua Zeng2, Jindan Yu2,3,4

  • 1Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, Illinois 60208, United States.

Journal of Medicinal Chemistry
|December 7, 2020
PubMed
Summary

Polycomb Repressive Complex 2 (PRC2) is crucial for gene silencing and cell differentiation. New small molecules targeting PRC2 are being developed as potential anticancer therapeutics by inhibiting its function or disrupting its complex formation.

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