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Related Concept Videos

Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

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Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
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Parametric Survival Analysis: Weibull and Exponential Methods01:14

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Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
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One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

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This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
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Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

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Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
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Determination of Renal Drug Clearance: Graphical and Midpoint Methods01:07

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Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
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Receiver Operating Characteristic Plot01:15

Receiver Operating Characteristic Plot

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A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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A Nomogram Combing Peripheral Parameters for Estimation of CRSwNP Recurrence.

Kun Du1, Ming Zheng1, Yan Zhao2

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

American Journal of Rhinology & Allergy
|December 7, 2020
PubMed
Summary

Predicting chronic rhinosinusitis with nasal polyps (CRSwNP) recurrence is challenging. A new nomogram using blood eosinophils, IgE levels, asthma, and prior surgeries may help predict CRSwNP recurrence before surgery.

Keywords:
asthmachronic rhinosinusitisendoscopic sinus surgeryeosinophilsimmunoglobulin Enasal polypsnomogrampredictionprognosisrecurrence

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Area of Science:

  • Otolaryngology
  • Immunology
  • Surgical Outcomes

Background:

  • Preoperative prediction of recurrence in chronic rhinosinusitis with nasal polyps (CRSwNP) is clinically challenging.
  • Identifying patients at high risk for CRSwNP recurrence is crucial for effective management.

Purpose of the Study:

  • To develop and validate a predictive nomogram for CRSwNP recurrence.
  • To integrate peripheral risk factors into a clinical tool for preoperative risk assessment.

Main Methods:

  • A retrospective study involving 158 CRSwNP patients who underwent endoscopic sinus surgery (ESS).
  • Patients were divided into training (n=96) and validation (n=62) cohorts.
  • Logistic regression identified risk factors for nomogram construction.

Main Results:

  • Recurrence rates were 29.2% (training) and 35.5% (validation).
  • Independent predictors of recurrence included serum IgE level and prior ESS.
  • The developed nomogram demonstrated good predictive accuracy (C-index 0.81 training, 0.80 validation).

Conclusions:

  • A nomogram combining objective parameters can potentially predict CRSwNP recurrence preoperatively.
  • This tool may aid in clinical decision-making for CRSwNP management.
  • Further validation is needed to confirm the nomogram's reliability and effectiveness.