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Inherited Chromosomally Integrated Human Herpesvirus 6: An Unexpected Finding in a Septic Neonate

Lorenza Pugni1, Carlo Pietrasanta1,2, Andrea Ronchi1

  • 1From the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, NICU, Milan, Italy.

The Pediatric Infectious Disease Journal
|December 7, 2020
PubMed

Human herpesvirus 6 (HHV-6) can integrate its genome in human chromosomes and be germline transmitted (inherited chromosomally integrated HHV-6). We report a case of chromosomally integrated HHV-6 inherited from the mother unexpectedly diagnosed in a septic neonate. Since HHV-6 has recently been included in multiplex polymerase chain reaction assays for meningitis/encephalitis, diagnosing inherited chromosomally integrated HHV-6 status is essential to avoid misdiagnosis of active HHV-6 infection and unnecessary antiviral treatment.

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