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Successful treatment of advanced ovarian cancer with anlotinib: a case report

Ping Zhang1, Liangliang Ma1, Xiaojie Wang1

  • 1Department of Oncology, Dezhou People's Hospital, Dezhou, P.R. China.

The Journal of International Medical Research
|December 7, 2020
PubMed

Insights

Anlotinib monotherapy shows promise for advanced ovarian cancer patients who have not responded to chemotherapy. This treatment led to a partial response and extended progression-free survival with manageable side effects.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Ovarian cancer is a lethal gynecological malignancy with high relapse rates in advanced stages.
  • Anlotinib, an oral multi-targeted tyrosine kinase inhibitor, inhibits tumor growth and neoangiogenesis.

Observation:

  • A case study of an elderly woman with advanced ovarian cancer post-multiple chemotherapy failure.
  • The patient received anlotinib monotherapy.

Findings:

  • Partial response observed after six cycles of anlotinib.
  • Significant reduction in serum CA125 levels (1832.7 to 118.7 U/mL) and metastatic size.
  • Progression-free survival exceeded 4 months with mild hypertension as the primary side effect.

Implications:

  • Anlotinib monotherapy may represent a novel therapeutic strategy for advanced ovarian cancer.
  • Further investigation into anlotinib for ovarian cancer is warranted.
Keywords:
Anlotinibadvanced ovarian cancermetastasismonotherapysurvivaltargeted therapy

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