Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

14.2K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.2K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.2K
4.2K
Protein Networks02:26

Protein Networks

4.3K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.3K
Protein Networks02:26

Protein Networks

2.6K
2.6K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.7K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.7K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.0K
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionary signals in metabolic networks of insect endosymbionts revealed through comparative topological modeling.

BMC genomics·2026
Same author

Metadag: a web tool to generate and analyse metabolic networks.

BMC bioinformatics·2025
Same author

The <i>k</i>-Robinson-Foulds Dissimilarity Measures for Comparison of Labeled Trees.

Journal of computational biology : a journal of computational molecular cell biology·2024
Same author

Towards estimating the number of strains that make up a natural bacterial population.

Nature communications·2024
Same author

Exploring the expressiveness of abstract metabolic networks.

PloS one·2023
Same author

Editorial: Influence of Protein-Protein Interactions (PPIs) on the Outcome of Viral Infections.

Frontiers in microbiology·2022

Related Experiment Video

Updated: Nov 27, 2025

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

11.4K

Alignment of virus-host protein-protein interaction networks by integer linear programming: SARS-CoV-2.

Mercè Llabrés1, Gabriel Valiente2

  • 1Department of Mathematics and Computer Science, University of the Balearic Islands, Palma de Mallorca, Spain.

Plos One
|December 7, 2020
PubMed
Summary

This study aligns virus-host protein networks for SARS-CoV-1 and SARS-CoV-2. The alignment reveals key human proteins involved in viral infection, aiding drug discovery efforts.

More Related Videos

Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.6K
Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

8.2K

Related Experiment Videos

Last Updated: Nov 27, 2025

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

11.4K
Engineering Antiviral Agents via Surface Plasmon Resonance
13:00

Engineering Antiviral Agents via Surface Plasmon Resonance

Published on: June 14, 2022

2.6K
Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

8.2K

Area of Science:

  • Virology
  • Computational Biology
  • Network Science

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has intensified research into virus-host interactions.
  • Understanding virus-host protein-protein interactions is crucial for identifying therapeutic targets and drug discovery.

Purpose of the Study:

  • To adapt and apply an integer linear programming model for aligning virus-host protein-protein interaction networks.
  • To analyze the conserved and novel interactions between SARS-CoV-1, SARS-CoV-2, and human proteins.

Main Methods:

  • Utilized an integer linear programming model for network alignment.
  • Applied the model to SARS-CoV-1 and SARS-CoV-2 virus-host protein-protein interaction networks.
  • Generated a consensus alignment to identify shared and functionally similar host proteins.

Main Results:

  • Achieved a consensus alignment of SARS-CoV-1 and SARS-CoV-2 virus-host networks.
  • Identified aligned human proteins with functions relevant to viral infection, despite limited shared proteins and interactions.
  • Highlighted functionally similar human proteins interacting with viral proteins, suggesting potential therapeutic targets.

Conclusions:

  • Network alignment is a valuable approach for studying virus-host interactions, even with divergent viral proteins.
  • The identified host proteins represent potential targets for broad-spectrum antiviral drug development against coronaviruses.
  • This method can guide future research in understanding viral pathogenesis and designing antiviral therapies.