Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The DNA Helix01:07

The DNA Helix

27.9K
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
27.9K
The DNA Helix01:16

The DNA Helix

152.8K
Overview
152.8K
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

2.7K
Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
2.7K
DNA Packaging00:58

DNA Packaging

110.6K
Overview
110.6K
DNA as a Genetic Template02:05

DNA as a Genetic Template

25.2K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
25.2K
Chromatin Packaging01:32

Chromatin Packaging

18.4K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
18.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tip functionalization of anisotropic plasmonic nanoparticles with conductive polymer patches via site-selective micelle intercalation.

Nature communications·2026
Same author

Strain, Chain, Repeat: Synthesis and Optoelectronic Properties of Poly(Naphthalene Benzene Vinylene)s.

ACS macro letters·2026
Same author

Light-tunable DNA interactions enable spatiotemporal assembly and relaxation-driven crystallization of colloids.

Soft matter·2026
Same author

Cholesteric Liquid Crystal Microdroplets with Dual-Mode Structural Color Enabling Programmable Thermochromic Displays.

ACS applied materials & interfaces·2026
Same author

Multipatch Colloids via DNA Ligation.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Crystallization of non-convex colloids: the roles of particle shape and entropy.

Soft matter·2025

Related Experiment Video

Updated: Nov 27, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.9K

Two-Dimensional (2D) or Quasi-2D Superstructures from DNA-Coated Colloidal Particles.

Mingzhu Liu1, Xiaolong Zheng1, Veronica Grebe1

  • 1Molecular Design Institute, Department of Chemistry, New York University, New York, NY, 10003, USA.

Angewandte Chemie (International Ed. in English)
|December 7, 2020
PubMed
Summary

Researchers created DNA-functionalized colloidal particles that self-assemble into diverse 2D superstructures. Tuning particle design and conditions allows control over assembly, guiding the creation of novel materials.

Keywords:
2D patternsDNA-coated colloidsdi-patch particlesself-assemblysuperstructures

More Related Videos

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.9K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.9K

Related Experiment Videos

Last Updated: Nov 27, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.9K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.9K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

11.9K

Area of Science:

  • Colloid science
  • Materials science
  • Nanotechnology

Background:

  • Colloidal particles offer tunable building blocks for advanced materials.
  • Controlling self-assembly is key to designing complex material architectures.

Purpose of the Study:

  • To synthesize and characterize DNA-functionalized di-patch colloidal particles.
  • To investigate the self-assembly behavior of these particles into ordered superstructures.
  • To establish a phase diagram for predicting and controlling superstructure formation.

Main Methods:

  • Synthesis of di-patch colloidal particles with DNA functionalization.
  • Utilizing cooperative depletion and DNA-mediated interactions for assembly.
  • Systematic variation of particle patch sizes and assembly conditions.
  • Analysis of resulting colloidal superstructures (e.g., Kagome, honeycomb).

Main Results:

  • Achieved controlled assembly into various 2D superstructures including flower-like Kagome, brick-wall monolayers, orthogonal layers, wrinkled monolayers, and honeycomb lattices.
  • Developed an empirical phase diagram correlating particle parameters and assembly conditions with emergent superstructures.
  • Demonstrated tunability of assembly by adjusting patch size and environmental conditions.

Conclusions:

  • The study provides fundamental principles for designing 2D colloidal materials with specific superstructures.
  • The developed phase diagram serves as a predictive tool for materials design.
  • The strategy shows potential for translation to the assembly of three-dimensional (3D) colloidal structures.