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High expression of microRNA 221 is a poor predictor for glioma

Yanlin Song1,2, Min He3, Jing Zhang1

  • 1Department of Neurosurgery and National Clinical Research Center for Geriatrics.

Medicine
|December 8, 2020
PubMed
Abstract

Insights

High microRNA 221 expression indicates a poor prognosis for glioma patients. This meta-analysis confirms its role in predicting overall survival and disease-free survival, aiding future glioma research.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Research

Background:

  • MicroRNA 221 (miR-221) is implicated as a potential biomarker in various cancers.
  • Previous studies on miR-221's role in glioma prognosis have yielded conflicting results.
  • A systematic evaluation is needed to clarify the prognostic significance of miR-221 in glioma.

Purpose of the Study:

  • To conduct a meta-analysis systematically evaluating the prognostic role of microRNA 221 in glioma.
  • To synthesize existing evidence regarding the association between miR-221 expression and patient outcomes in glioma.

Main Methods:

  • Comprehensive literature search across major databases (PubMed, Web of Science, EMBASE, Cochrane Library, CNKI).
  • Extraction of relevant data and characteristics from eligible studies.
  • Pooled analysis of Hazard Ratios (HRs) with 95% Confidence Intervals (CIs) to assess prognostic value.

Main Results:

  • Eight studies comprising 1069 glioma patients were included in the meta-analysis.
  • Elevated miR-221 expression was significantly associated with poorer overall survival (HR = 1.66, 95% CI: 1.34-2.04).
  • Increased miR-221 levels also correlated with reduced disease-free survival (HR = 1.14, 95% CI: 1.02-1.26).

Conclusions:

  • High expression of microRNA 221 is linked to unfavorable prognosis in glioma patients.
  • These findings support miR-221 as a potential predictive biomarker for glioma.
  • Further research is recommended to address the heterogeneity observed across studies and solidify clinical application.

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