[Therapeutic pathomorphosis of bone tumors]

A comparative study of therapeutic pathomorphosis of bone tumors has shown that radiosensitive and radioresistant tumors differ in the time-course and nature of radiation-induced pathomorphosis. In radiosensitive tumors, the resultant changes arise earlier, are more strongly marked, and, as a rule, necrosis of the tumor with its replacement with fibrous tissue is observed. In radioresistant tumors, signs of radiation pathomorphosis appear later, "therapeutic giants" are typically seen to appear, and the direction in which tumor cell differentiate may change.