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Cardiovascular toxicity and tricyclic antidepressants
W K Jackson1, S P Roose, A H Glassman
1Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, N.Y. 10032.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1987
Abstract:
This article reviews the cardiovascular effects of the standard tricyclic antidepressants and what is known of the cardiovascular effects of the newer antidepressants. The cardiovascular effects of the standard tricyclics are orthostatic hypotension, conduction delay and a potent antiarrhythmic effect. Patients who have congestive heart failure and are on cardiac medications are at greatly increased risk for orthostatic hypotension, while patients who have pre-existing conduction delay are at risk for heart block.