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14-3-3σ and Its Modulators in Cancer

Ghazi Aljabal1, Beow Keat Yap1

  • 1School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor 11800, Penang, Malaysia.

Pharmaceuticals (Basel, Switzerland)
|December 8, 2020
PubMed

Insights

14-3-3σ protein is vital for controlling tumor growth and apoptosis. This review details recent protein-protein interaction modulators, offering insights for developing new cancer therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • 14-3-3σ is an acidic homodimer protein involved in oncogenic signaling and cell cycle regulation.
  • It interacts with over one hundred protein partners, influencing critical cellular processes.

Purpose of the Study:

  • To review the role of 14-3-3σ in tumor growth and apoptosis.
  • To discuss structure-activity relationships and binding interactions of recent 14-3-3σ protein-protein interaction (PPI) modulators.
  • To explore binding mechanisms and discovery strategies for novel 14-3-3σ modulators.

Main Methods:

  • Literature review of recent studies on 14-3-3σ modulators.
  • Analysis of structure-activity relationships and binding interactions.
  • Discussion of various chemical classes of modulators and discovery techniques.

Main Results:

  • Recent modulators include fusicoccanes, fragment stabilizers, phosphate-based inhibitors, peptide inhibitors, and natural product inhibitors.
  • Insights into binding mechanisms of existing modulators have been elucidated.
  • Various strategies and techniques for discovering new 14-3-3σ modulators are presented.

Conclusions:

  • 14-3-3σ plays a critical role in cancer, making it a promising therapeutic target.
  • Understanding PPI modulators is key to developing targeted cancer therapies.
  • This review serves as a guide for future development of 14-3-3σ modulators for cancer treatment.
Keywords:
14-3-3σcancerdimerinhibitorprotein-protein interaction (PPI)stabilizer

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