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Impact of Pulse Wave Velocity and Parameters Reflecting Android Type Fat Distribution on Left Ventricular Diastolic

Marlena Paniczko1, Małgorzata Chlabicz1,2, Jacek Jamiołkowski1

  • 1Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, 15-269 Bialystok, Poland.

Journal of Clinical Medicine
|December 8, 2020
PubMed

Insights

Left ventricular diastolic dysfunction (LVDD) is common in chronic coronary syndromes (CCS). Android fat distribution, aortic stiffness, and reduced handgrip strength are key associated factors.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Echocardiography

Background:

  • Left ventricular diastolic dysfunction (LVDD) impairs relaxation, increasing heart failure (HF) risk and mortality.
  • Chronic coronary syndromes (CCS) are frequently associated with LVDD.

Purpose of the Study:

  • To determine the prevalence of LVDD in patients with CCS.
  • To identify factors associated with LVDD in this population.

Main Methods:

  • Echocardiography was used to diagnose LVDD in 200 patients with CCS.
  • Patient data included age, sex, N-terminal pro-brain natriuretic peptide (NT-proBNP), fat mass ratio, left ventricular mass index (LVMI), Z-score, left ventricular ejection fraction (LVEF), pulse wave velocity, handgrip strength, and waist-to-hip ratio (WHR).

Main Results:

  • LVDD was diagnosed in 38.5% of the CCS patients.
  • Factors associated with LVDD included android/gynoid fat mass ratio, LVMI, and negatively with Z-score and LVEF, independent of NT-proBNP.
  • Pulse wave velocity, handgrip strength, and WHR were the strongest predictors of LVDD.

Conclusions:

  • LVDD is prevalent in CCS patients and linked to android fat distribution and aortic stiffness.
  • Increased aortic stiffness is independently associated with diastolic dysfunction.
  • Further research on physical fitness and abdominal fat reduction in CCS patients with LVDD is warranted.
Abstract

Keywords:
android fat distributionchronic coronary syndromesleft ventricular diastolic dysfunction

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