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Galectin-3 in Cardiovascular Diseases.

Valeria Blanda1,2, Umberto Marcello Bracale3, Maria Donata Di Taranto1,4

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International Journal of Molecular Sciences
|December 8, 2020
PubMed
Summary
This summary is machine-generated.

Galectin-3 (Gal-3) is a key protein involved in cardiovascular diseases, promoting inflammation and fibrosis. Inhibiting Gal-3 shows potential for treating conditions like heart failure and atherosclerosis.

Keywords:
Galectin-3atherosclerosisbiomarkercardiovascular diseasesinflammation

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Area of Science:

  • Biochemistry
  • Cardiology
  • Molecular Biology

Background:

  • Galectin-3 (Gal-3) is a β-galactoside-binding protein with diverse cellular functions.
  • Gal-3 plays a significant role in inflammation, fibrosis, and angiogenesis.
  • It is implicated in various diseases, including cardiovascular diseases (CVDs).

Purpose of the Study:

  • To review the association between Gal-3 and cardiovascular diseases.
  • To explore Gal-3's role in atherogenesis, plaque stability, cardiac fibrosis, and heart failure.
  • To discuss Gal-3 as a diagnostic and prognostic marker and potential therapeutic target.

Main Methods:

  • Literature review of studies on Gal-3 and CVDs.
  • Analysis of biological roles and molecular mechanisms of Gal-3.
  • Evaluation of Gal-3 as a biomarker and therapeutic target.

Main Results:

  • Gal-3 contributes to the pro-inflammatory process in atherosclerosis and influences plaque stability.
  • It is involved in cardiac fibrosis, myocardial remodeling, heart failure, and atrial fibrillation.
  • Gal-3 serves as a prognostic marker for heart failure and has potential diagnostic applications.

Conclusions:

  • Gal-3 is a critical mediator in the pathogenesis of cardiovascular diseases.
  • Targeting Gal-3 may offer a therapeutic strategy for preventing cardiac inflammation and fibrosis.
  • Further research is warranted to fully elucidate Gal-3's role and therapeutic potential in CVDs.