Hydrogen sulfide: Roles in plant abiotic stress response and crosstalk with other signals

Hydrogen sulfide (H₂S) has been recently recognized as an endogenous gas transmitter alongside nitric oxide and carbon monoxide. Exposure of plants to H₂S, for example through applicating H₂S donors, reveals that H₂S play important roles in plant response to abiotic stresses such as heavy metals, salinity, drought and extreme temperatures. Sodium hydrosulfide is the most widely used donor in plants due to its direct and instantaneous release of H₂S, followed by GYY4137. H₂S can enhance plant tolerance to salt and heavy metal stresses through regulating Na⁺/K⁺ homeostasis and the uptake and transport of metal ions. H₂S also promotes the H₂S-Cys cycle balance under abiotic stress and enhances its roles in regulation of the antioxidant system, alternative respiratory pathway, and heavy metal chelators synthesis. H₂S coordinates with gaseous signal molecules, reactive oxygen species and nitric oxide to respond to stress directly through influencing their generation or competing for the regulation of the downstream signaling. Moreover, H₂S interacts with phytohormones including abscisic acid, ethylene, salicylic acid and melatonin as well as polyamines to regulate plant response to abiotic stresses. In this review, the application of H₂S donors and their functional mechanism are summarized. We propose promising new research directions, which can lead to new insights on the role of this gastrasmitter during plant growth and development.