Related Experiment Video
Updated: Nov 26, 2025

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
Treating pediatric colorectal patients in low and middle income settings: Creative adaptation to the resources
Giulia Brisighelli1, Victor Etwire2, Taiwo Lawal3
1Department of Pediatric Surgery, Pediatric Colorectal and Pelvic Reconstruction Centre, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, 7 York Road, Parktown, 2193 Johannesburg, South Africa.
Insights
Pediatric colorectal diseases in low- and middle-income countries present late and with complications. Infectious diseases and trauma significantly impact treatment, necessitating adapted approaches for better outcomes.
Area of Science:
- Pediatric surgery
- Colorectal surgery
- Global health
Background:
- Colorectal disease in children in low- and middle-income countries (LMIC) often presents late, leading to increased complications and limited follow-up.
- Infectious diseases like tuberculosis (TB), human immunodeficiency virus (HIV), and human papilloma virus (HPV) are prevalent and complicate primary colorectal conditions.
- Perineal trauma from various causes and endemic conditions present unique challenges in LMIC settings.
Purpose of the Study:
- To discuss the unique profiles of pediatric colorectal diseases in LMIC.
- To highlight the impact of infectious diseases and trauma on colorectal care.
- To explore adaptations needed for resource-poor healthcare settings.
Main Methods:
- Review of existing literature and clinical observations on pediatric colorectal diseases in LMIC.
- Discussion of specific endemic conditions and their management challenges.
- Analysis of the impact of socioeconomic factors on colorectal care.
Main Results:
- Late presentation and complications are characteristic of pediatric colorectal diseases in LMIC.
- Infectious agents (TB, HIV, HPV) and perineal trauma significantly affect wound healing and surgical outcomes.
- Unique conditions like congenital pouch colon and H-type rectal fistulae require specialized management.
Conclusions:
- Pediatric colorectal care in LMIC requires creative adaptations due to unique disease profiles and resource limitations.
- Addressing socioeconomic factors and endemic conditions is crucial for optimizing treatment.
- Further research is needed to understand and manage specific endemic colorectal diseases in LMIC.
Abstract:
Colorectal disease profiles for children in low- and middle-income settings (LMIC) are characterized by late presentation, increased complications and limited follow-up in many cases. There is a high prevalence of infectious conditions causing secondary colorectal disease such as Mycobacterium Tuberculosis(TB), Human Immunodeficiency Virus(HIV) and Human Papilloma Virus(HPV), which also impact the management of other primary colorectal conditions, such as wound-healing and intestinal anastomosis. Perineal trauma from sexual assault, motor vehicle or pedestrian accidents, burns, and traditional enemas are commonly encountered and may require adaptation of principles used in treatment of congenital anomalies such as Hirschsprung's disease and Anorectal Malformations for reconstruction. Endemic conditions in certain LMIC require further research to delineate underlying causes and optimize management, such as "African" degenerative visceral leiomyopathy, congenital pouch colon in the Indian subcontinent, and congenital H-type rectal fistulae prevalent in Asia. These unique disease profiles require creative adaptations of resources within poor healthcare infrastructure settings. These special challenges and pitfalls in colorectal care and complications of adverse socioeconomic conditions, are discussed.
More Related Videos
06:28E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
03:43Structured Approach to Colonoscopy Technique Optimization: A Single-Center Experience with Novice Endoscopists
Published on: July 11, 2025
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...