Amelanotic Malignant Melanoma in a Himalayan Rex Guinea Pig (Cavia porcellus)
Lisa Allnoch1, Saskia Köstlinger2, Nicole Steffensen3
1Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany.
Journal of Comparative Pathology
|December 8, 2020
Abstract:
A Himalayan Rex guinea pig was presented with a history of nodular, partially ulcerated masses in the subcutis of the left shoulder. Histological examination revealed a garland-like to nodular, infiltrative neoplastic mass of the epidermis and hair follicle epithelium, which obscured the dermoepidermal junction. Neoplastic cells were immunopositive for S100, PNL-2, vimentin and melan-A antigens. No immunolabelling of CD3, CD79, Iba-1 or pancytokeratin was observed. This is the first detailed description of spontaneous amelanotic malignant melanoma in this species.


