Clustered Circulating Tumor Cells in Lung Adenocarcinoma: Implications of Test Results of Continuous Variables
Takashi Watanabe1,2, Noriyoshi Sawabata3,4, Takeshi Kawaguchi2
1Department of General Thoracic Surgery, Nara Prefectural General Medical Center, Nara, Japan.
Background/Aim:
We investigated the relationship between solid component size (SS), carcinoembryonic antigen (CEA), and standardized uptake value (SUVmax) as continuous variables and postoperative clustered circulating tumor cell (C-CTC) detection in patients with pulmonary adenocarcinoma who underwent surgery.
Patients And Methods:
C-CTC detection was the main evaluation item, which was analyzed using the receiver operating characteristic curve to calculate areas under the curves (AUCs) for the variables. Additionally, the two-year recurrence-free survival rates (2Y-RFSRs) were analyzed.
Results:
Among the 84 patients examined, SS, CEA, and SUVmax had AUCs>0.7, and were independent. Their thresholds were 2.1 cm, 7.5 ng/ml, and 2.9, respectively. The 2Y-RFSR were significantly better in the non-C-CTC group (n=58) and in the group of patients without high levels of these predictors (n=32).
Conclusion:
SS, CEA level, and SUVmax predicted postoperative CTC detection in pulmonary adenocarcinoma patients.
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