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Tools for experimental and computational analyses of off-target editing by programmable nucleases

X Robert Bao1,2, Yidan Pan3, Ciaran M Lee4

  • 1ILISATech, Houston, TX, USA.

Nature Protocols
|December 8, 2020
PubMed
Summary

Genome editing tools show promise but off-target effects are a concern. Combining in silico and experimental methods with next-generation sequencing (NGS) is recommended for accurate off-target analysis in therapeutic applications.

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