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FGF23, Frailty, and Falls in SPRINT
Anna Jovanovich1,2, Charles Ginsberg3, Zhiying You2
1VA Eastern Colorado Healthcare System, Aurora, Colorado.
Journal of the American Geriatrics Society
|December 8, 2020
Summary
Fibroblast growth factor 23 (FGF23) is linked to frailty and increased fall risk in individuals with chronic kidney disease (CKD). This study highlights FGF23 as a potential biomarker for adverse outcomes in CKD patients.
Area of Science:
- Nephrology
- Geriatrics
- Endocrinology
Background:
- Chronic kidney disease (CKD) is a known risk factor for frailty.
- Elevated Fibroblast Growth Factor 23 (FGF23) levels are observed in CKD patients.
- FGF23 association with frailty is established in non-CKD populations but unknown in CKD.
Purpose of the Study:
- To investigate the association between FGF23 and frailty in CKD patients.
- To examine the relationship between FGF23 and the risk of falls in individuals with CKD.
Main Methods:
- Cross-sectional and longitudinal observational study design.
- Utilized data from 2,376 participants with CKD in the Systolic Blood Pressure Intervention Trial (SPRINT).
- Employed multinomial logistic regression and Cox proportional hazards analysis, adjusting for multiple covariates.
Main Results:
- A twofold increase in FGF23 was associated with a 1.34-fold increased odds of prevalent frailty.
- Highest FGF23 quartile showed a 2.32-fold increased risk of incident falls.
- A twofold increase in FGF23 correlated with a 1.99-fold increased hazard of falls.
Conclusions:
- FGF23 is significantly associated with prevalent frailty in CKD patients.
- Elevated FGF23 levels predict an increased risk of falls in individuals with CKD.
- FGF23 may serve as a biomarker for frailty and falls in the context of CKD.
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