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Updated: Nov 26, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

Serological tests for COVID-19: Potential opportunities.

Marcarious M Tantuoyir^1,2,3, Nima Rezaei^1,4,5

¹School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Cell Biology International

|December 8, 2020

Summary

This study explores the role of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies, along with viral antigens, in diagnosing SARS-CoV-2 infection and understanding disease progression, including recurrent positive tests.

Keywords:

IgG IgM SARS-CoV-2 antibody coronavirus diagnosis

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Published on: April 6, 2021

Area of Science:

Virology
Immunology
Infectious Diseases

Background:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic.
Controversies exist regarding the production of specific IgM and IgG antibodies post-SARS-CoV-2 infection.

Purpose of the Study:

To elaborate on the diagnostic potential of IgM and IgG antibodies and viral antigens.
To investigate the application of these markers in disease course monitoring.
To explore their role in recurrent positive nucleic acid tests after discharge.

Main Methods:

Review of existing literature on SARS-CoV-2 antibody and antigen detection.
Analysis of diagnostic strategies utilizing serological markers.
Examination of data related to viral shedding and nucleic acid testing.

Main Results:

IgM and IgG antibody profiles offer insights into infection timing and immune response.
Viral antigens aid in early diagnosis and disease activity assessment.
Serological markers may help explain persistent or recurrent positive nucleic acid tests.

Conclusions:

IgM and IgG antibodies, alongside viral antigens, are valuable tools for SARS-CoV-2 diagnosis and management.
Understanding antibody dynamics is crucial for interpreting disease course and post-discharge findings.
Further research can refine the use of these markers for improved patient outcomes.