Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy
Mengyu Chang1,2, Zhiyao Hou1,3,4, Man Wang5
1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
Advanced Materials (Deerfield Beach, Fla.)
|December 8, 2020
Summary
Hyperthermia therapy (HTT) combined with cancer immunotherapy shows promise for treating tumors. This synergistic approach enhances immune responses, combats cancer recurrence, and improves survival rates.
Area of Science:
- Oncology
- Immunology
- Nanomedicine
Background:
- Hyperthermia therapy (HTT), including photothermal therapy (PTT) and magnetic hyperthermia (MHT), is an emerging strategy for malignant tumors.
- While effective and noninvasive, PTT and MHT alone cannot completely cure cancer due to recurrence and metastasis.
- Cancer immunotherapy has gained attention for its ability to harness the body's immune system against cancer cells.
Purpose of the Study:
- To discuss the synergistic mechanisms of HTT in cancer immunotherapy.
- To summarize combination strategies of HTT with immunotherapy.
- To review challenges and future directions in HTT-synergized immunotherapy.
Main Methods:
- Review of literature on hyperthermia therapy and cancer immunotherapy.
- Analysis of synergistic mechanisms, including immunogenic cell death and reversal of immunosuppressive tumor microenvironment.
- Summary of combination therapies: HTT with immunoadjuvants, immune checkpoint blockade, and adoptive cellular immunotherapy.
Main Results:
- HTT can activate immune responses against tumors.
- Combination strategies demonstrate synergistic therapeutic outcomes against primary and metastatic tumors.
- These combined approaches show potential in preventing cancer recurrence and prolonging survival.
Conclusions:
- Combining hyperthermia therapy with cancer immunotherapy offers enhanced treatment efficacy.
- Synergistic strategies can overcome limitations of individual therapies, leading to improved patient outcomes.
- Further research and development are needed to address current challenges and optimize HTT-synergized immunotherapy.
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