Related Experiment Video
Updated: Nov 26, 2025
11:27
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
2.3K
A new olanzapine cocrystal obtained from volatile deep eutectic solvents and determined by 3D electron diffraction
Iryna Andrusenko1, Jason Potticary2, Simon R Hall2
1Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, Pisa, Italy.
Summary
A novel cocrystal of olanzapine and phenol was discovered during olanzapine crystallization. This nanocrystalline phase, stabilized by weak interactions, offers insights into pharmaceutical cocrystal formation.
Area of Science:
- Crystal Engineering
- Pharmaceutical Science
- Materials Chemistry
Background:
- Olanzapine is an antipsychotic medication.
- Cocrystallization is a key strategy in pharmaceutical development to modify drug properties.
- Deep eutectic solvents offer unique environments for crystal formation.
Purpose of the Study:
- To identify and characterize a previously unknown cocrystal of olanzapine.
- To investigate the structural features and stabilization mechanisms of this new phase.
- To understand the role of volatile deep eutectic solvents in pharmaceutical crystallization.
Main Methods:
- Cocrystallization from a volatile deep eutectic solvent.
- Nanocrystalline phase characterization using electron diffraction, powder X-ray diffraction, and differential scanning calorimetry.
- Structure determination via simulated annealing with 3D electron diffraction data and DFT-D optimizations.
Main Results:
- Identification of a new olanzapine-phenol cocrystal.
- Determination of the triclinic crystal structure (space group P1).
- Evidence for a dimeric growth unit stabilized by C-H...π interactions and N-H...N hydrogen bonding.
Conclusions:
- The identified cocrystal represents an intermediate species in olanzapine crystallization.
- The structural findings support a dimeric growth mechanism.
- This research advances the understanding of cocrystal formation and stabilization in pharmaceutical contexts.
