Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atomic Force Microscopy01:08

Atomic Force Microscopy

3.9K
Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
3.9K
Surface Appendages of Archaea01:23

Surface Appendages of Archaea

406
Archaeal surface appendages are highly specialized structures essential for environmental adaptation, encompassing roles in adhesion, biofilm formation, and motility. Among these appendages, pili and archaella stand out for their distinct morphologies and functionalities, enabling archaea to thrive in diverse and often extreme environments.Pili: Adhesion and Biofilm FormationPili are filamentous structures assembled from pilin protein subunits, primarily contributing to adhesion and biofilm...
406

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing the Antibacterial Activity of Zinc-Based Layered Double Hydroxide Nanoparticles in the Presence of UV<sub>A</sub> Light.

ACS omega·2026
Same author

Full-length Tau disrupts fluid zwitterionic supported lipid bilayers.

Biophysical chemistry·2026
Same author

Structural Basis of the Membrane Association by the Conserved RocS Membrane-Targeting Sequence in Streptococcus.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Surface-dependent reorganization of <i>Chlorella vulgaris</i> cell wall components revealed by AFM and SRS microscopy.

Cell surface (Amsterdam, Netherlands)·2025
Same author

Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology.

Nature·2025
Same author

Probing Bacterial Interactions with the <i>Schistosoma mansoni</i>-Killing Toxin Biomphalysin via Atomic Force Microscopy and Single Molecule Force Spectroscopy.

Toxins·2025

Related Experiment Video

Updated: Nov 26, 2025

Investigating Single Molecule Adhesion by Atomic Force Spectroscopy
09:48

Investigating Single Molecule Adhesion by Atomic Force Spectroscopy

Published on: February 27, 2015

10.6K

The microbial adhesive arsenal deciphered by atomic force microscopy.

Audrey Beaussart1, Cécile Feuillie, Sofiane El-Kirat-Chatel

  • 1Université de Lorraine, CNRS, LIEC, F-54000 Nancy, France.

Nanoscale
|December 8, 2020
PubMed
Summary

Atomic force microscopy (AFM) reveals how microbes stick to surfaces by examining single cells and molecules. This powerful tool helps develop new anti-adhesion strategies against microbial colonization.

More Related Videos

Bacterial Immobilization for Imaging by Atomic Force Microscopy
10:03

Bacterial Immobilization for Imaging by Atomic Force Microscopy

Published on: August 10, 2011

17.7K
Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry
08:51

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry

Published on: September 15, 2020

4.4K

Related Experiment Videos

Last Updated: Nov 26, 2025

Investigating Single Molecule Adhesion by Atomic Force Spectroscopy
09:48

Investigating Single Molecule Adhesion by Atomic Force Spectroscopy

Published on: February 27, 2015

10.6K
Bacterial Immobilization for Imaging by Atomic Force Microscopy
10:03

Bacterial Immobilization for Imaging by Atomic Force Microscopy

Published on: August 10, 2011

17.7K
Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry
08:51

Atomic Force Microscopy Combined with Infrared Spectroscopy as a Tool to Probe Single Bacterium Chemistry

Published on: September 15, 2020

4.4K

Area of Science:

  • Microbiology
  • Biophysics
  • Surface Science

Background:

  • Microbes utilize diverse strategies, including appendages and adhesion proteins, to attach to surfaces and host cells.
  • Surface physicochemical properties significantly influence microbial adhesion dynamics.

Purpose of the Study:

  • To review the application of Atomic Force Microscopy (AFM) in understanding microbial adhesion mechanisms.
  • To highlight AFM's role in deciphering microbial adhesive strategies and developing anti-adhesion approaches.

Main Methods:

  • Atomic Force Microscopy (AFM) for high-resolution imaging of microbial cell wall topography.
  • AFM for probing adhesion forces at both single-cell and single-molecule resolution.

Main Results:

  • AFM imaging provides unprecedented resolution of live microbial cell surface organization.
  • AFM enables detailed analysis of molecular interactions driving microbial adhesion.
  • AFM facilitates the study of microbial adhesion across multiple scales, from molecular to cellular.

Conclusions:

  • AFM is an indispensable tool for elucidating the complexities of microbial adhesion.
  • AFM-driven insights are crucial for developing novel anti-adhesive strategies to combat microbial colonization.