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Related Concept Videos

Overview of Cell Signaling01:23

Overview of Cell Signaling

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
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What is Cell Signaling?02:03

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Cell-matrix's Response to Mechanical Forces01:13

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
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Related Experiment Video

Updated: Nov 26, 2025

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
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Correction: Long-range mechanical signaling in biological systems.

Farid Alisafaei1, Xingyu Chen1, Thomas Leahy2

  • 1Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA 19104, USA. janmey@pennmedicine.upenn.edu vshenoy@seas.upenn.edu and Department of Materials Science and Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

Soft Matter
|December 8, 2020
PubMed
Summary

This correction clarifies long-range mechanical signaling in biological systems. It ensures accurate understanding of how cells communicate physically over distances.

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Area of Science:

  • Biophysics
  • Cell Biology
  • Mechanobiology

Context:

  • Addresses a correction for a previously published article.
  • Focuses on the physical communication mechanisms within biological systems.

Purpose:

  • To provide an accurate and corrected version of the original study.
  • To ensure the scientific record reflects precise findings on mechanical signaling.

Summary:

  • Corrects specific details within the original research on long-range mechanical signaling.
  • Ensures clarity and accuracy in the description of physical signaling pathways in biology.

Impact:

  • Enhances the reliability of research in mechanobiology.
  • Facilitates accurate future studies on cellular physical communication.
  • Supports the understanding of biological system mechanics.