Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

1.3K
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
1.3K
Aryldiazonium Salts to Azo Dyes: Diazo Coupling01:11

Aryldiazonium Salts to Azo Dyes: Diazo Coupling

3.3K
The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para...
3.3K
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

539
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
539
Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

3.1K
Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
3.1K
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions01:20

Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions

2.2K
Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
2.2K
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

343
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
343

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Charging Pyracylene: Steering Aromaticity and Reactivity of [12]Annulene by Substitution.

Journal of the American Chemical Society·2026
Same author

Post-Modification of Tripyrenylenes to Enantiopure π-Extended D<sub>3</sub>-Symmetric Propellers.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Copper-Catalyzed Domino Strategy Construction of Fused Benzopyrroloazepinone through the Reaction of Allenyloximes and Arylboronic Acids.

Organic letters·2026
Same author

Palladium-Catalyzed Approach to Highly Luminescent <i>para</i>-Difuropyrazines.

The Journal of organic chemistry·2026
Same author

Synthesis of Soft Octahedral Nanoparticles through Supramolecular Self-Assembly of <i>C</i><sub>3</sub>-Symmetric Trinaphthylamine Trisamides.

Journal of the American Chemical Society·2026
Same author

Toward Larger Cyclo-9,10-Anthryleneparaphenylenes.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026

Related Experiment Video

Updated: Nov 26, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

12.2K

Diazapentacenes from Quinacridones.

Thomas Wiesner1, Lukas Ahrens1, Frank Rominger1

  • 1Organisch Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|December 8, 2020
PubMed
Summary

New diazapentacene molecules were synthesized and their solid-state packing and optical properties were studied. The arrangement of substituents and nitrogen atoms significantly impacts these characteristics, offering insights for material design.

Keywords:
azaacenesphotostabilityquinacridinessemiconductorssolid-state packing

More Related Videos

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
09:04

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Published on: September 9, 2016

10.9K
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
07:12

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

Published on: July 17, 2020

6.5K

Related Experiment Videos

Last Updated: Nov 26, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

12.2K
A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
09:04

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Published on: September 9, 2016

10.9K
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
07:12

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions

Published on: July 17, 2020

6.5K

Area of Science:

  • Organic Chemistry
  • Materials Science
  • Photophysics

Background:

  • Diazapentacenes are nitrogen-containing polycyclic aromatic hydrocarbons with potential applications in organic electronics.
  • Controlling molecular packing and optical properties is crucial for designing advanced functional materials.

Purpose of the Study:

  • To synthesize novel bis(silylethynylated) diazapentacenes.
  • To investigate the influence of substituent position and nitrogen atom placement on solid-state packing.
  • To understand how structural modifications affect the optical properties of these compounds.

Main Methods:

  • Synthesis of bis(silylethynylated) 5,7- and 5,12-diazapentacenes from quinacridone precursors.
  • Utilizing protection, alkynylation, and deoxygenation strategies.
  • Analysis of solid-state packing through crystallographic methods (implied).
  • Characterization of optical properties (spectroscopy implied).

Main Results:

  • Successful synthesis of target bis(silylethynylated) diazapentacenes.
  • Demonstration that solid-state packing is dictated by the type and position of silylethynyl substituents.
  • Observation that substituent and nitrogen atom positions modulate optical properties.

Conclusions:

  • The synthetic route provides access to functionalized diazapentacenes.
  • Molecular structure, specifically substituent and nitrogen placement, is a key determinant of material properties.
  • These findings are valuable for the rational design of organic electronic materials.