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Maternal lipodome across pregnancy is associated with the neonatal DNA methylome

Jennifer L LaBarre1,2, Carolyn F McCabe2, Tamara R Jones3

  • 1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Epigenomics
|December 8, 2020
PubMed

Aim: To classify the association between the maternal lipidome and DNA methylation in cord blood leukocytes. Materials & methods: Untargeted lipidomics was performed on first trimester maternal plasma (M1) and delivery maternal plasma (M3) in 100 mothers from the Michigan Mother-Infant Pairs cohort. Cord blood leukocyte DNA methylation was profiled using the Infinium EPIC bead array and empirical Bayes modeling identified differential DNA methylation related to maternal lipid groups. Results: M3-saturated lysophosphatidylcholine was associated with 45 differentially methylated loci and M3-saturated lysophosphatidylethanolamine was associated with 18 differentially methylated loci. Biological pathways enriched among differentially methylated loci by M3 saturated lysophosphatidylcholines were related to cell proliferation and growth. Conclusion: The maternal lipidome may be influential in establishing the infant epigenome.

Keywords:
DNA methylationdevelopmental epigeneticsepigenome-wide association studieslipidomicslysophospholipidspregnancyumbilical cord blood

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