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COVID-19 in Children With Cancer: A Single Low-Middle Income Center Experience

Fatma S E Ebeid1,2, Iman A Ragab1, Nayera H K Elsherif1

  • 1Pediatric Hematology Oncology Department.

Journal of Pediatric Hematology/Oncology
|December 8, 2020
PubMed

Insights

In hospitalized pediatric cancer patients, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was often asymptomatic or mild. Regular screening is recommended for early detection in this vulnerable population.

Area of Science:

  • Pediatric Oncology
  • Infectious Diseases
  • Virology

Background:

  • Coronavirus disease-2019 (COVID-19) poses risks to immunocompromised children.
  • Understanding SARS-CoV-2 prevalence in pediatric cancer patients is crucial.

Purpose of the Study:

  • To determine the frequency of SARS-CoV-2 infection in hospitalized children with cancer.
  • To identify clinical symptoms and outcomes associated with SARS-CoV-2 in this group.

Main Methods:

  • Prospective study of hospitalized children with cancer (April-June 2020).
  • SARS-CoV-2 diagnosis via nasopharyngeal swab reverse transcription polymerase chain reaction (RT-PCR).
  • Collection of clinical, laboratory, and radiological data.

Main Results:

  • SARS-CoV-2 detected in 15 of 61 (24.6%) hospitalized cancer patients.
  • Most infected children (66.7%) were asymptomatic initially; 33.3% had mild symptoms like fever or cough.
  • Baseline laboratory tests and imaging were not consistently diagnostic for SARS-CoV-2.

Conclusions:

  • Pediatric cancer patients with COVID-19 frequently present with asymptomatic or mild illness.
  • High index of suspicion and routine SARS-CoV-2 screening are recommended for hospitalized pediatric cancer patients.
Abstract

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