Assembly of Indole Cores through a Palladium-Catalyzed Metathesis of Ar-X σ-Bonds
Farnaz Jafarpour1,2,3,2,1,4, Mehran Ghasemi1,2,3,2,1,4, Hamed Navid1,2,3,2,1,4
1Faculty of Chemistry, Kharazmi University, No. 43. Mofateh Street, Enghelab Ave., 15719-14911 Tehran, Iran.
Abstract:
We describe the development of a new method for construction of highly substituted indole scaffolds through the strategic utilizing of the metathesis of Ar-X σ-bonds based on the dynamic nature of palladium-based oxidative addition/reductive elimination. A suitable and simple catalytic system has provided an appropriate platform for a productive ligand exchange and consecutive carbopalladation/C-H activation/amination of phosphine ligands with alkynes and aromatic/aliphatic amines for construction of structurally diverse indoles.
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