Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

42.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
42.2K
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

3.2K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
3.2K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

1.9K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.9K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

12.0K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
12.0K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

767
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
767
Neuroplasticity01:01

Neuroplasticity

1.2K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experience-dependent modulation of collective behavior in larval zebrafish.

Nature communications·2026
Same author

Artificial light pollution disrupts sleep and neuronal genomic stability in wild reef fish.

Current biology : CB·2026
Same author

A neuron-glia circuit anticipates hypoxia to regulate organismal oxygen use.

bioRxiv : the preprint server for biology·2026
Same author

A lineage-based model of scalable positional information in vertebrate brain development.

Neuron·2026
Same author

Social interactions in medaka fish depend on discrete kinematic states of swimming behavior.

Current biology : CB·2026
Same author

Synchronization of behavioral and cardiac dynamics in larval zebrafish.

Cell reports·2026

Related Experiment Video

Updated: Nov 26, 2025

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

9.1K

Neuromodulation: How Dopaminergic Neurons Shape and Modulate Behavior.

Florian Engert1

  • 1Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.

Current Biology : CB
|December 8, 2020
PubMed
Summary
This summary is machine-generated.

Researchers identified dopaminergic neuron classes in zebrafish. These neurons control specific motor sequences, offering new insights into brain function and behavior.

More Related Videos

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

472
Primary Culture of Mouse Dopaminergic Neurons
11:58

Primary Culture of Mouse Dopaminergic Neurons

Published on: September 8, 2014

38.8K

Related Experiment Videos

Last Updated: Nov 26, 2025

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

9.1K
Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

472
Primary Culture of Mouse Dopaminergic Neurons
11:58

Primary Culture of Mouse Dopaminergic Neurons

Published on: September 8, 2014

38.8K

Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Zebrafish Models

Background:

  • The precise roles of dopaminergic neurons in modulating, structuring, and executing behaviors remain incompletely understood.
  • Dopaminergic signaling is crucial for various brain functions, including motor control and learning.

Purpose of the Study:

  • To elucidate the specific functions of different dopaminergic neuron classes in motor control.
  • To map the projection patterns and functional properties of dopaminergic neurons in larval zebrafish.

Main Methods:

  • Utilized larval zebrafish as a model organism.
  • Classified dopaminergic neurons based on their anatomical projection patterns.
  • Investigated functional properties and roles in motor sequence initiation.

Main Results:

  • Identified distinct classes of dopaminergic neurons in larval zebrafish.
  • Demonstrated that specific dopaminergic neuron classes initiate particular motor sequences.
  • Correlated neuron projection patterns with functional roles in behavior.

Conclusions:

  • Dopaminergic neurons are not a homogenous group; distinct classes have specialized roles.
  • This study provides a framework for understanding how dopaminergic systems orchestrate complex behaviors.
  • Findings advance our knowledge of neural circuits underlying motor control and behavior generation.