Related Experiment Video

Updated: Nov 26, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.9K

Advances in biological therapies for dyslipidemias and atherosclerosis

Eftaxia-Konstantina Valanti1, Katerina Dalakoura-Karagkouni2, Gerasimos Siasos3

  • 14th Department of Internal Medicine, Clinical Genomics and Pharmacogenomics Unit, 'Attikon' Hospital, Medical School, National and Kapodistrian University of Athens, Greece; Molecular Biology Division, Biomedical Research Foundation of the Academy of Athens, Greece; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Metabolism: Clinical and Experimental
|December 8, 2020
PubMed

Insights

Targeting genes in lipoprotein metabolism offers new ways to prevent and treat atherosclerosis. Approved therapies show promise, with ongoing research into advanced strategies like gene editing and vaccines.

Area of Science:

  • Cardiovascular Research
  • Genetics and Molecular Biology
  • Pharmacology

Background:

  • Atherosclerosis is a complex disease with significant global mortality.
  • Current treatments reduce cardiovascular event risk but don't eliminate mortality.
  • Lipoprotein metabolism gene targeting is a promising therapeutic avenue.

Purpose of the Study:

  • To review emerging strategies for atherosclerosis prevention and treatment.
  • To focus on monoclonal antibodies, vaccines, and genome/transcriptome modification.
  • To discuss the clinical potential and challenges of these novel therapies.

Main Methods:

  • Review of current literature on advanced atherosclerosis therapies.
  • Analysis of monoclonal antibodies, vaccines, and gene-based strategies.
  • Examination of FDA-approved biological therapies and ongoing clinical trials.

Main Results:

  • Several lipid-lowering biological therapies are FDA-approved with positive outcomes.
  • Monoclonal antibodies and vaccines show potential for atherosclerosis management.
  • Genome/transcriptome modification strategies (gene therapy, editing) are under investigation.

Conclusions:

  • Targeting lipoprotein metabolism genes is a key emerging strategy.
  • Advanced therapies offer new hope for reducing atherosclerosis-related mortality.
  • Continued research and clinical trials are essential for therapeutic advancement.
Keywords:
Antisense oligonucleotides (ASOs)Gene therapyGenome/base editingImmunotherapyMonoclonal antibodies (mAbs)Precision medicineVaccines

More Related Videos

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

12.0K
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.6K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
156
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.1K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
443
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
685
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
93
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
685