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Updated: Nov 26, 2025
The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood
Published on: February 7, 2025
Neutrophils and COVID-19: The road so far
Luiz Henrique Agra Cavalcante-Silva1, Deyse Cristina Madruga Carvalho1, Éssia de Almeida Lima1
1Laboratório de Imunobiotecnologia, Centro de Biotecnologia, Universidade Federal da Paraíba (UFPB), João Pessoa, Brazil.
Abstract:
The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-19, a pandemic disease. This disease is characterized by acute respiratory distress syndrome, cytokine-driven hyperinflammation, and leukocytes count changes. The innate immune response has been linked to COVID-19 immunopathogenesis (e.g., dysfunctional IFN response and myeloid inflammation). In this regard, neutrophils have been highlighted as essential effector cells in the development of COVID-19. This review summarized the significant finds about neutrophils and its effector mechanisms (e.g., neutrophils enzymes and cytokines, neutrophil extracellular traps) in COVID-19 so far.
