Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

198
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
198
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

151
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
151
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

216
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
216
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

87
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
87
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

275
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
275
Renal Corpuscle01:20

Renal Corpuscle

5.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics and outcomes of intensive care patients receiving metaraminol infusion-a retrospective observational cohort study.

Anaesthesia and intensive care·2026
Same author

Characteristics, management, and outcomes of segmental and subsegmental pulmonary embolism in ICU patients: A retrospective cohort study.

PloS one·2026
Same author

Association of clinical characteristics to mortality in acute respiratory failure patients treated with ECCO<sub>2</sub>R.

The International journal of artificial organs·2026
Same author

Beyond equipoise: why automated ventilation trials should measure what really matters.

Critical care science·2026
Same author

Mortality effect of albumin fluid resuscitation in adults with septic shock: a systematic review and dual frequentist-bayesian meta-analysis of randomised trials.

Critical care (London, England)·2026
Same author

Evaluation of the clinical impact of different telemedicine practices in intensive care units: A stepped-wedge cluster randomized clinical trial (TELESCOPE 2): Study protocol.

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine·2026

Related Experiment Video

Updated: Nov 26, 2025

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.2K

NephroCheck® Quality Test.

Thummaporn Naorungroj1,2, Ary Serpa Neto1,3,4,5,6, Fumitaka Yanase1,5

  • 1Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia.

Blood Purification
|December 8, 2020
PubMed
Summary
This summary is machine-generated.

The NephroCheck® test for acute kidney injury (AKI) risk scores is stable when urine samples are frozen at -20°C or -80°C for up to 8 weeks. This stability allows for flexible urine collection and storage without specialized equipment.

Keywords:
Acute kidney injuryAcute kidney injury risk scoreCritical careInsulin-like growth factor binding protein-7Tissue inhibitor of metalloproteinases-2

More Related Videos

Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.2K
Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
08:15

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

10.4K

Related Experiment Videos

Last Updated: Nov 26, 2025

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

14.2K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.2K
Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method
08:15

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

10.4K

Area of Science:

  • Clinical diagnostics
  • Biomarker stability
  • Renal medicine

Background:

  • The acute kidney injury (AKI) risk score aids in predicting moderate to severe AKI within 12-24 hours.
  • Accurate urine collection is crucial for reliable AKI risk score results.

Discussion:

  • This study assessed the stability of the NephroCheck® assay in urine samples stored at -20°C and -80°C for 8 weeks.
  • Comparison of AKI risk scores from fresh urine versus frozen samples demonstrated high correlation.
  • The findings indicate that standard freezing protocols do not significantly affect NephroCheck® results.

Key Insights:

  • NephroCheck® AKI risk scores remain stable in urine samples stored at -20°C or -80°C for up to 8 weeks.
  • Urine collection for AKI risk assessment can be performed without immediate laboratory processing or specialized cold chain logistics like dry ice.
  • The study validates the reliability of frozen urine samples for AKI risk score determination.

Outlook:

  • This research supports the feasibility of decentralized urine collection for AKI risk assessment.
  • Future studies could explore longer-term stability or stability under different storage conditions.
  • The findings may facilitate wider adoption of AKI risk scoring in clinical practice.