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Isolation and Selection of Entomopathogenic Fungi from Soil Samples and Evaluation of Fungal Virulence against Insect Pests

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New Eugenol Derivatives with Enhanced Insecticidal Activity.

Maria José G Fernandes¹, Renato B Pereira², David M Pereira²

¹Centre of Chemistry, Department of Chemistry, Campus of Gualtar, University of Minho, 4710-057 Braga, Portugal.

International Journal of Molecular Sciences

|December 9, 2020

Summary

This summary is machine-generated.

New eugenol derivatives show potent insecticidal activity by inducing programmed cell death in insect cells. These plant-derived compounds offer potential as novel, semisynthetic insecticides.

Keywords:

Spodoptera frugiperda eugenol derivatives natural product-derived insecticides phenylpropanoids semisynthetic insecticides

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Area of Science:

Natural Product Chemistry
Insect Toxicology
Molecular Biology

Background:

Eugenol, a major component of clove oil, possesses known antimicrobial and antioxidant properties.
The biological potential of eugenol derivatives remains an area of active research.
Exploring plant natural products for novel insecticide development is crucial.

Purpose of the Study:

To synthesize novel O-alkylated eugenol derivatives and their corresponding oxiranes.
To evaluate the insecticidal activity of these derivatives against the Sf9 insect cell line.
To investigate the mechanism of cell death and potential human toxicity of promising compounds.

Main Methods:

Synthesis of O-alkylated eugenol derivatives and epoxidation to oxiranes.
Assessment of insect cell viability (Sf9) upon treatment with synthesized compounds.
Morphological analysis, caspase-like activity assays, and human cell toxicity evaluations.

Main Results:

Structural modifications of eugenol significantly impacted insecticidal potency.
Certain derivatives exhibited high toxicity towards Sf9 insect cells.
Morphological changes and caspase-like activity indicated programmed cell death induction in insect cells.
Preliminary assessment of human cell toxicity was conducted.

Conclusions:

O-alkylated eugenol derivatives and their oxiranes demonstrate significant insecticidal potential.
These compounds induce programmed cell death in insect cells, confirming their mechanism of action.
Eugenol derivatives represent promising semisynthetic insecticides derived from natural products.