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Updated: Nov 26, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
The nuclear receptor 4A family members: mediators in human disease and autophagy
Liqun Chen1,2, Fengtian Fan3,4, Lingjuan Wu3,4
1College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350108, China. lqchen@fzu.edu.cn.
Abstract:
The Nuclear receptor 4A (NR4A) subfamily, which belongs to the nuclear receptor (NR) superfamily, has three members: NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1). They are gene regulators with broad involvement in various signaling pathways and human disease responses, including autophagy. Here, we provide a concise overview of the current understanding of the role of the NR4A subfamily members in human diseases and review the research into their regulation of cell autophagy. A deeper understanding of these mechanisms has potential to improve drug development processes and disease therapy.
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