Related Experiment Video

Updated: Nov 26, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.9K

Vitamin D and Covid-19: an update on evidence and potential therapeutic implications

Giuseppe Murdaca1, Giovanni Pioggia2, Simone Negrini3

  • 1Department of Internal Medicine, University of Genoa and IRCCS Ospedale Policlinico San Martino, Viale Benedetto XV, n. 6, 16132, Genova, Italy. giuseppe.murdaca@unige.it.

Clinical and Molecular Allergy : CMA
|December 9, 2020
PubMed

Insights

Vitamin D may help reduce risks associated with coronavirus (CoV) infections like COVID-19, but its effectiveness and optimal dosage require further clinical study. More research is needed to confirm benefits for viral infections.

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • The recent emergence of coronavirus (CoV) causing COVID-19 presents a global health challenge.
  • COVID-19 symptoms include fever, cough, and dyspnea, with characteristic lung opacities.
  • Vitamin D plays a role in immune function and has shown benefits in other viral infections.

Purpose of the Study:

  • To investigate the potential role and controversial effects of vitamin D supplementation in COVID-19 patients.
  • To explore vitamin D's mechanisms in combating microbial infections and reducing mortality.
  • To highlight the need for further research on vitamin D's impact on COVID-19 outcomes.

Main Methods:

  • Review of existing literature on vitamin D's immunological functions.
  • Analysis of studies examining vitamin D supplementation in viral infections.
  • Identification of gaps in current knowledge regarding vitamin D and COVID-19.

Main Results:

  • Vitamin D exhibits multiple mechanisms that can reduce the risk of microbial infection and death.
  • Previous studies suggest favorable effects of vitamin D in influenza and HIV infections.
  • The specific impact of vitamin D supplementation on COVID-19 remains debated.

Conclusions:

  • Further clinical studies are essential to determine optimal vitamin D levels and effective dosages for COVID-19.
  • Understanding vitamin D's role could inform public health strategies against viral epidemics.
  • Clarifying the controversy surrounding vitamin D and COVID-19 is crucial for patient care.

Keywords:
Covid-19Vitamin D

More Related Videos

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

5.7K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-208:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.1K

Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.1K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.8K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
4.5K
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
1.9K
Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
83
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
93