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Published on: October 28, 2019
Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome
Jie Xu1, Xiao-Qi Zhang2, Zaijun Zhang3
1Guangdong Provincial Engineering Research Center for Modernization of TCM, Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of TCM and New Drug Research, College of Pharmacy, Jinan University, 510632, Guangzhou, People's Republic of China.
Abstract:
Autophagy is a highly conserved degradation process for long-lived intracellular proteins and organelles mediated by lysosomes. Deficits in the autophagy-lysosome pathway (ALP) have been linked to a variety of human diseases, including neurodegenerative diseases, lysosomal storage disorders, and cancers. Transcription factor EB (TFEB) has been identified as a major regulator of autophagy and lysosomal biogenesis. Increasing evidence has demonstrated that TFEB activation can promote the clearance of toxic protein aggregates and regulate cellular metabolism. Traditional Chinese medicine (TCM)-derived natural products as important sources for drug discovery have been widely used for the treatment of various diseases associated with ALP dysfunction. Herein, we review (1) the regulation of TFEB and ALP; (2) TFEB and ALP dysregulation in human diseases; (3) TFEB activators from natural products and their potential uses.
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