Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CRISPR/Cas9-germline editing of <i>Biomphalaria glabrata</i>: A breakthrough in genetic modification of snails that transmit schistosomiasis.

Science advances·2025
Same author

Fast and artifact-free circular dichroism measurement of solid-state structural changes.

Chirality·2023
Same author

Role of B Cell-Activating Factor in Fibrosis Progression in a Murine Model of Non-Alcoholic Steatohepatitis.

International journal of molecular sciences·2023
Same author

Comparable outcomes between a combination of peritoneal dialysis with once-weekly haemodialysis and thrice-weekly haemodialysis: a prospective cohort study.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2023
Same author

Saline suppression to distinguish the primary aldosteronism subtype: a diagnostic study.

European journal of endocrinology·2023
Same author

Clinical Usefulness of Surgical Resection Including the Complementary Use of Radiofrequency Ablation for Intermediate-Stage Hepatocellular Carcinoma.

Cancers·2023

Related Experiment Video

Updated: Nov 26, 2025

Effect of Male Accessory Gland Products on Egg Laying in Gastropod Molluscs
15:19

Effect of Male Accessory Gland Products on Egg Laying in Gastropod Molluscs

Published on: June 22, 2014

11.0K

The pond snail Lymnaea stagnalis.

Reiko Kuroda1, Masanori Abe2

  • 1Frontier Research Institute, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi, 487-8501, Japan. rkuroda@isc.chubu.ac.jp.

Evodevo
|December 9, 2020
PubMed
Summary

The freshwater snail Lymnaea stagnalis is a key model for studying developmental biology and neurodegenerative diseases. A gene-editing approach identified the Lsdia1 gene as the determinant of shell coiling handedness.

Keywords:
CRISPR/Cas9ChiromorphogenesisLearning/memoryNeurodegenerative diseasesSchistosomiasisSpiral cleavage

More Related Videos

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis
07:33

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis

Published on: March 15, 2016

9.1K
Long-term Video Tracking of Cohoused Aquatic Animals: A Case Study of the Daily Locomotor Activity of the Norway Lobster Nephrops norvegicus
05:57

Long-term Video Tracking of Cohoused Aquatic Animals: A Case Study of the Daily Locomotor Activity of the Norway Lobster Nephrops norvegicus

Published on: April 8, 2019

7.1K

Related Experiment Videos

Last Updated: Nov 26, 2025

Effect of Male Accessory Gland Products on Egg Laying in Gastropod Molluscs
15:19

Effect of Male Accessory Gland Products on Egg Laying in Gastropod Molluscs

Published on: June 22, 2014

11.0K
A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis
07:33

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis

Published on: March 15, 2016

9.1K
Long-term Video Tracking of Cohoused Aquatic Animals: A Case Study of the Daily Locomotor Activity of the Norway Lobster Nephrops norvegicus
05:57

Long-term Video Tracking of Cohoused Aquatic Animals: A Case Study of the Daily Locomotor Activity of the Norway Lobster Nephrops norvegicus

Published on: April 8, 2019

7.1K

Area of Science:

  • Developmental Biology
  • Translational Medicine
  • Neuroscience

Background:

  • Lymnaea stagnalis, a freshwater snail, is a long-established research organism.
  • It is increasingly used to study molecular mechanisms in developmental biology, learning/memory, and neurodegenerative diseases.
  • Its hermaphroditic nature and mating capabilities facilitate genetic studies.

Purpose of the Study:

  • To review the use of Lymnaea stagnalis as a model organism.
  • To highlight research on chiromorphogenesis (body-handedness) and shell coiling.
  • To discuss the identification of the handedness determinant gene.

Main Methods:

  • Review of existing literature on Lymnaea stagnalis.
  • Focus on gene-editing approaches.
  • Analysis of maternal inheritance patterns.

Main Results:

  • Lymnaea stagnalis is a valuable model for complex biological processes.
  • Chirality in shell coiling (chiromorphogenesis) is a key research area.
  • The actin-related gene Lsdia1 was identified as the primary determinant of handedness.

Conclusions:

  • Lymnaea stagnalis offers unique advantages for genetic and developmental research.
  • Understanding chiromorphogenesis in this model provides insights into fundamental biological mechanisms.
  • The identification of Lsdia1 advances molecular studies in developmental biology and related fields.