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Thymidine kinase 1 through the ages: a comprehensive review
Eliza E Bitter1, Michelle H Townsend2, Rachel Erickson2
1Department of Microbiology and Molecular Biology, Brigham Young University, 701 E University Pkwy, LSB room 4007, Provo, UT, 84602, USA. bitter.eliza@gmail.com.
Cell & Bioscience
|December 9, 2020
Summary
Thymidine kinase 1 (TK1) shows promise as a superior cancer biomarker. Its serum levels correlate with cancer stage and prognosis, aiding in monitoring recurrence and treatment effectiveness.
Area of Science:
- Biochemistry
- Oncology
- Molecular Biology
Background:
- Proliferation markers like PCNA, Ki-67, and TK1 are crucial for cancer diagnostics and prognostics.
- TK1's role in DNA salvage pathway and its early upregulation in cancer development are established.
- Serum TK1 levels correlate with cancer stage, indicating prognostic value.
Purpose of the Study:
- To review the significance of TK1 as a diagnostic and prognostic biomarker in cancer.
- To explore TK1's regulation, role in pathogenesis, and potential as a therapeutic target.
- To compare TK1 with existing proliferation markers for cancer assessment.
Main Methods:
- Review of existing literature on TK1 discoveries and findings.
- Analysis of TK1 regulation from DNA to protein levels.
- Examination of recent studies on TK1's role in cancer and its biomarker potential.
Main Results:
- TK1 upregulation is an early event in cancer development.
- Serum TK1 levels are linked to cancer stage and prognosis.
- TK1 may be more advantageous than current biomarkers for monitoring cancer.
Conclusions:
- TK1 is a promising biomarker for cancer recurrence, treatment monitoring, and survival.
- TK1 levels accurately determine DNA synthesis rates in tumors.
- TK1 holds potential as a tumor biomarker and therapeutic target.
