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Related Experiment Video

Updated: Nov 26, 2025

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
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Recent progress on peripheral neural interface technology towards bioelectronic medicine.

Youngjun Cho1, Jaeu Park1, Chengkuo Lee2,3,4

  • 1Daegu Geongbuk Institute of Science and Technology (DGIST), Daegu, 42899, Republic of Korea.

Bioelectronic Medicine
|December 9, 2020
PubMed
Summary
This summary is machine-generated.

Peripheral nervous system (PNS) modulation offers therapeutic potential. This review covers advanced neural interfaces for autonomic nerves, including wireless and self-sustainable designs, and non-invasive stimulation methods.

Keywords:
Bioelectronic medicineEnergy harvestersMagnetic stimulationPeripheral nerve interfaceUltrasound stimulationWireless neural interface

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Area of Science:

  • Bioelectronic Medicine
  • Neuroscience
  • Biomedical Engineering

Background:

  • The peripheral nervous system (PNS), particularly autonomic nerves, plays a crucial role in regulating organ physiology and chronic disease states.
  • Targeted modulation of autonomic nerves holds significant therapeutic potential for restoring bodily functions.
  • Effective bioelectronic neuromodulation relies on reliable neural interfaces for stimulating and recording nerve activity, necessitating energy delivery.

Purpose of the Study:

  • To provide an overview of the state-of-the-art in peripheral neural interface technology specifically for autonomic nerves.
  • To discuss the current status of wireless neural interfaces for peripheral nerve applications.
  • To present recent advancements in self-sustainable and non-invasive neural stimulation techniques.

Main Methods:

  • Review of current literature on peripheral neural interface technologies for autonomic nerve modulation.
  • Analysis of existing wireless neural interface systems for peripheral nerve applications.
  • Exploration of novel concepts like self-sustainable interfaces and non-invasive stimulation methods (ultrasound, magnetic).

Main Results:

  • The development of advanced neural interfaces is crucial for next-generation bioelectronic medicine targeting autonomic nerves.
  • Wireless and self-sustainable neural interfaces are emerging as promising solutions to overcome physiological and anatomical challenges.
  • Non-invasive stimulation techniques like ultrasound and magnetic stimulation are showing potential for peripheral nerve applications.

Conclusions:

  • Significant progress has been made in peripheral neural interface technology for autonomic nerves.
  • Future research should focus on developing robust, efficient, and minimally invasive interfaces for bioelectronic medicine.
  • The integration of wireless, self-sustainable, and non-invasive approaches will drive the future of autonomic nerve modulation.